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No precise dose adjustment advised when tofacitinib coadministered with powerful CYP2C19 inhibitors; lower tofacitinib dose if coadministered with both of those reasonable CYP3A4 and strong CYP2C19 inhibitors .When you miss out on a dose, acquire it the moment you can. If it is almost time on your future dose, take only that dose. Tend not to choos